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Darvish encountered trouble early, allowing three singles and a walk in the first. Eddie Rosario singled to put the Twins ahead before Darvish struck out the side.
Kepler’s groundout extended the lead to 2-0 after Jake Cave tripled to lead off the second inning.
The Twins have won three of seven.
Willson Contreras led off the fourth with a double for the Cubs and advanced on a groundout but was thrown out at home on Javier Báez’s grounder to third.
The Cubs recalled outfielder/infielder José Martínez from its alternate site in South Bend, Ind., and optioned left-handed pitcher Josh Osich to South Bend before the game.
Twins: DH Nelson Cruz (sore knee) was out of the lineup for the second consecutive day. With Monday an off day, Cruz — who had been playing with the injury can take advantage of three days of rest manager Rocco Baldelli said.
Cubs: RHP Tyler Chatwood (right forearm strain) threw from 105 feet Saturday. Surgery has not been discussed for him, general manager Jed Hoyer said. … Cameron Maybin replaced Kyle Schwarber in LF in the third inning. No reason was announced.
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