Live Cell Encapsulation technology is enclosing of live cells in protective “capsules” sized of the head of a pin, designed to allow blood to enter and nourish the living cells inside them.

Live Cell Encapsulation technology is a methodology allowing implantation of xenogeneic cells while isolating the cells from host immune response allowing blood to enter and nourish the living cells inside them. The encapsulation technology was first incorporated around 9 decades ago in a report of 1934 that described the encapsulation of tumor cells in a polymer as well as implanting the capsules in the abdominal cavity of a pig.

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Cell encapsulation is probably the solution for most of the chronic disease, which had not yet been attended by most of the pharmaceutical therapeutics. The cellular system might possibly enable seamless treatment in upcoming years as certain clinical trials are evaluating the use of encapsulated cells for several human diseases.

Cell encapsulation includes immobilization of xenogeneic cells within a semipermeable, yet in immunoprotective membrane. Thus, it offers therapeutics’ without requiring immunosuppression. Potentials of the therapeutics have been taken from two key instances; islet cell delivery for diabetes and MSCs-based therapies.

“I think diabetes is where this type of technology really lends itself to the application. The key is to develop the right type of cell line to treat Type 1 and insulin-dependent Type 2 diabetes. There are several cell lines being explored by PharmaCyte simultaneously to do this,” said David A. Judd, a cellular biologist and a member of PharmaCyte’s Medical and Scientific Advisory Board in a press release. PharmaCyte Biotech, a global biotechnology company that has been in the market for a while now and is already developing therapies for both diabetes and cancer using cell-based cell encapsulation technology (Cell-in-a-Box).

The technology further is the representation of a process with an ample amount of applications. These when combined together offers an ability of preserving cells within the encapsulation matrix. The applications include:

Additionally, below are the hardware devices of e-smell technology have 2 major divisions as per the report:

• Tissue fabrication and 3D printing of cell
• Enhancing therapeutic cell delivery
• Creating in 3D cell cultures for pharmacological screening and testing its toxicity if any
• Upstream bioprocessing of cells

The global market for live cell encapsulation has a highly competitive landscape with large number of players developing cell-based therapies. Despite the market having a huge scope, there are certain limitations impeding it growth, like lack of technical skills, limited availability of high quality raw material and the significant adoption of alternative therapies as per the report by The Insight partners.

Top Dominating Players

– Balchem Corporation
– Biotime Inc.
– Blacktrace Group
– BUCHI Labortechnik AG
– Encapsys LLC
– Evonik Industries
– Living Cell Technologies
– Lycored
– Merck KGaA
– MiKroCaps

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The Live Cell Encapsulation Market is anticipated to grow in the forecast period owing to driving factors such as increasing public-private investments to support product development, rising research to establish the clinical efficacy of cell encapsulation technologies and rising public awareness related to the clinical role of encapsulated cells in disease management. Nevertheless, limited availability of high quality raw material and the significant adoption of alternative therapies are expected to impede the market growth during the forecast period.

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