A brand new white paper from Wyatt Technology explores real-time multi-angle mild scattering (RT-MALS) as a course of analytical expertise for monitoring and controlling nanomedicines and biopharmaceuticals  manufacturing processes. Additionally, it discusses the implementation of light-scattering-based on-line and in-line PAT.

Image Credit: ShutterStock/Anusorn Nakdee

For over three a long time, Wyatt’s analytical instrumentation has performed a key function within the improvement of biotherapeutics and nanomedicines. The firm’s merchandise are based mostly on dynamic light scattering (DLS) and multi-angle static light scattering (MALS).

While DLS and MALS are already vital for each product improvement and course of improvement through off-line detectors, they lack the flexibility to offer instantaneous suggestions to course of builders and manufacturing engineers. Wyatt’s ultraDAWN MALS detector supplies real-time capabilities for course of monitoring: it quantifies product attributes resembling molar mass, nanoparticle dimension and nanoparticle focus as much as 5 occasions per second. Implementation in-line or on-line with downstream processes generates a serious productiveness enhance, for the reason that knowledge can be utilized instantly to manage or tweak a course of.

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About Wyatt Technology

With a protracted historical past of excellence in scientific instrumentation, Wyatt Technology is the acknowledged chief in progressive mild scattering devices, equipment and software program for figuring out the properties of macromolecules and nanoparticles in resolution. Wyatt’s  cutting-edge options decide the scale, bodily titer, payload and zeta potential of nanoparticles, in addition to the molar mass, dimension, conformation, conjugation and interactions of macromolecules. With a workers composed of 25% Ph.D. scientists and lots of extra devoted and skilled help personnel, Wyatt’s goal is to please its buyer with one of the best merchandise, coaching, buyer help and repair accessible within the trade.

Published on
Feb 22, 2023