Roorkee: Researchers at the Indian Institute of Technology, Roorkee, have identified the role of specific immune cell markers on the outcomes of severe infection and sepsis. The research has provided important insights into the role of immune cell markers on sepsis-related complications.
The study — led by Professor Pranita P Sarangi, department of Biosciences and Bioengineering, IIT Roorkee — was funded by the BioCARe Women Scientist grant and Innovative Young Biotechnologist Award grant from the department of Biotechnology, Government of India.
According to researchers, neutrophils, monocytes and macrophages are white blood cells that act as scavengers of dead cells and foreign bodies such as bacteria and other pathogens. They move from the blood to the site of an infection to mop up the disease-causing foreign matter. However, in uncontrolled and severe infection, commonly called ‘sepsis’, there is abnormal activation and localisation of these immune cells. As a result, these cells form ensembles, move around the body, and get deposited in important organs such as the lung, kidney, and liver, which could lead to multi-organ failure or even death.
Speaking about the research, Prof Pranita P Sarangi said, “Given the importance of monocytes, macrophages and neutrophils in sepsis, it is important to understand the mechanism of the migration of such cells to detect the stages of inflammation and sepsis.”
Echoing a similar view, Shiba Prasad Dash, the lead researcher who is currently pursuing his PhD under Prof Sarangi, said, “These findings will help in detecting the stages of sepsis and appropriate treatment.”
Talking about the research Prof Ajit K Chaturvedi, director IIT Roorkee, said “The work advances the current understanding of sepsis biology and may be helpful in the development of therapeutics against this life-threatening condition.”
Results from this research work have been published in The Journal of Immunology, the official journal of the American Association of Immunologists (AAI) and presented at the international conferences organised by the Indian Immunology Society (Immunocon-2019).