Nik Turley (0-3) entered for the seventh, hitting César Hernández with a pitch and giving up a double to José Ramírez before Santana scored them both to put Cleveland ahead 7-6.

A sacrifice fly by Reyes drove in Santana, who hit a two-run homer in the third after promising acting manager Sandy Alomar Jr. that he would make up for his error in the second.

“I told Sandy, ‘No worries, I’ll get it back for us,’” said Santana, who went 3 for 3 with two doubles and three runs. “I live day to day, I play day to day and right now I’m focused on the baseball playoffs.”

James Karinchak (1-2) struck out all three batters he faced in the seventh for his first win in the majors. Hand got four outs for his AL-high 16th save in 16 opportunities.

Ramírez, a leading AL MVP contender, doubled twice and scored two runs. He batted .442 with six homers and 18 RBIs over the final 12 games.

“José, that’s my MVP there,” Reyes said. “The way he carried us at the end was big. Really big, big for the team.”

Pirates rookie Ke’Bryan Hayes singled in the first and homered in the third, becoming the first Pittsburgh player with eight straight hits since Andy Van Slyke in 1994.

The 23-year-old also reached base in 10 consecutive plate appearances and finished with a .376 batting average (32 for 85) after making his major league debut on Sept. 1.