Realmuto hit his 11th homer and had an RBI grounder as Philadelphia built a 6-3 lead in the fifth.

Alfaro had his third straight game with multiple RBIs for the Marlins.

Phillies starter Jake Arrieta allowed three runs, five hits and four walks in 5 2/3 innings. Marlins starter Sandy Alcantara gave up six runs — three earned — and seven hits in six innings, hurt by Alfaro’s passed ball and errors by Jesús Aguilar at first and Marte in center.

“It’s frustrating for all of us, but the one thing this team’s always done is it’s bounced back,” Phillies manager Joe Girardi said. “We went through this a couple of times this year, and they’ve got to do it again. It’s what they have to do. We don’t have a choice.”

Miami optioned RHP Jordan Yamamoto and LHP Alex Vesia to the alternate training site, and the Marlins recalled INF Isan Díaz and selected the contract of RHP Brett Eibner.

Phillies LHP José Álvarez (groin) is starting to take part in light activity, but Girardi doesn’t expect him to pitch again in the regular season. Álvarez took a 105.3 mph line drive off the bat of Toronto’s Lourdes Gurriel Jr. on Aug. 20.

Marlins: INF Jon Berti (index finger) was placed on the 10-day IL. Berti, batting .250 with 10 RBIs and eight steaks, was hurt while attempting a bunt in the 10th inning of Monday’s game against the Braves. … C Francisco Cervelli (concussion) was transferred to the 60-day IL, ending his season.