New Delhi, Apr 17 (PTI) Scientists have discovered a brand new method that mixes antibiotics with a protecting antidote to cut back their dangerous unwanted side effects with out compromising the effectivity of the medication.

The research, revealed within the journal Nature, analysed the results of 144 totally different antibiotics on the abundance of the commonest intestine micro organism.

Presented at this yr’s European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) in Copenhagen, Denmark from April 15-18, the analysis affords novel insights into decreasing the opposed results of antibiotic therapy on the intestine microbiome.

“The scientists identified a novel approach that combines antibiotics with a protective antidote to help keep the gut microbiome healthy and reduce the harmful side effects of antibiotics without compromising their efficiency,” stated Ulrike Lober, of the Max-Delbruck-Center for Molecular Medicine in Berlin, Germany.

“Despite our promising findings, further research is needed to identify optimum and personalized combinations of antidote drugs and to exclude any potential long-term effects on the gut microbiome,” Lober stated.

The trillions of microorganisms within the human intestine profoundly affect well being by aiding digestion, offering vitamins and metabolites, and dealing with the immune system to fend off dangerous micro organism and viruses.

Antibiotics can injury these microbial communities, leading to an imbalance that may result in recurrent gastrointestinal issues attributable to Clostridioides difficile infections in addition to long-term well being issues resembling weight problems, allergic reactions, bronchial asthma and different immunological or inflammatory illnesses.

The worldwide group of researchers systematically analysed the expansion and survival of 27 totally different bacterial species generally discovered within the intestine following therapy with 144 totally different antibiotics.

They additionally assessed the minimal inhibitory focus (MIC)—the minimal focus of an antibiotic required to cease micro organism from rising—for over 800 of those antibiotic-bacteria mixtures.

The outcomes confirmed that almost all of intestine micro organism had barely larger MICs than disease-causing micro organism, suggesting that at generally used antibiotic concentrations, many of the examined intestine micro organism wouldn’t be affected.

However, two extensively used antibiotic courses—tetracyclines and macrolides— stopped wholesome micro organism rising at a lot decrease concentrations than these required to cease the expansion of disease-causing micro organism, the researchers stated.

These antbiotics additionally killed greater than half of the intestine bacterial species examined, probably altering the intestine microbiome composition for a very long time, they stated.

As medication work together in another way throughout totally different bacterial species, the researchers investigated whether or not a second drug might be used to guard the intestine microbes.

They mixed the antibiotics erythromycin (a macrolide) and doxycycline (a tetracycline) with a set of 1,197 prescribed drugs to determine appropriate medication that might defend two considerable intestine bacterial species (Bacteriodes vulgatus and Bacteriodes uniformis) from the antibiotics.

The researchers recognized a number of promising medication together with the anticoagulant dicumarol, the gout medicine benzbromarone, and two anti-inflammatory medication, tolfenamic acid and diflunisal.

The research discovered that these medication didn’t compromise the effectiveness of the antibiotics in opposition to disease-causing micro organism.

Further experiments confirmed that these antidote medication additionally protected pure bacterial communities derived from human stool samples and in residing mice, the researchers added. PTI SAR SAR