ARPA-H Projects Take on Cancer, Organ Transplants, Superbugs, and Improving Immunity

This week, the Advanced Research Projects Agency for Health (ARPA-H), an company throughout the U.S. Department of Health and Human Services (HHS), introduced a sequence of analysis initiatives totaling over $330 million {dollars} that can assist biomedical well being breakthroughs geared toward bettering well being options and well being take care of the American public.

ARPA-H makes pivotal investments in breakthrough applied sciences and broadly relevant platforms, capabilities, assets, and options with the potential to remodel vital areas of medication and well being that can’t readily be completed by means of conventional analysis or business exercise. Last 12 months, as a part of his Unity Agenda, President Biden labored with Democrats and Republicans in Congress to determine and fund ARPA-H to drive breakthroughs to stop, detect, and deal with most cancers and different illnesses. ARPA-H is now shifting aggressively to advance the objectives of the Biden Cancer Moonshot and the President’s Unity Agenda, amongst different initiatives.

Read extra beneath:

Friday, September 29:

Biden-Harris Administration Announces up to $50 Million to Advance Health Data Security in America

The Advanced Research Projects Agency for Health (ARPA-H), an company throughout the U.S. Department of Health and Human Services, at this time introduced as much as $50 million in funding for six contract awards by means of the Digital Health Security (DIGIHEALS) undertaking, a digital safety undertaking to guard the U.S. well being care system’s digital infrastructure. The initiatives undertaken by means of these contract awards will search to advance applied sciences that tackle vulnerabilities in securing well being care information, resembling automated medical gadget patching, ransomware intervention, cognitive well being assistants for higher information group, cyber reasoning methods, and digital well being document consolidation.

Thursday, September 28:

Biden-Harris Administration announces major step to address organ transplant shortages through on-demand 3D tissue printing through ARPA-H award

The U.S. Department of Health and Human Services, by means of the Advanced Research Projects Agency for Health (ARPA-H), at this time introduced as much as $26 million for a newly funded undertaking, a part of its Open Broad Agency Announcement (Open BAA), that goals to put the groundwork for the event of 3D printed, fully-functional human organs. There are at present greater than 100,000 folks within the United States who’re ready for organs, resembling hearts or kidneys, and tragically, greater than 6,000 of those sufferers die annually on account of lack of entry to appropriate organs. That quantity is along with the tens of millions of Americans who want tissue – together with corneas, pores and skin, and cartilage – for grafts and transplants that might save or enhance their lives

Biden-Harris Administration announces funding for regenerative tissue project to restore immune system function and improve health outcomes through ARPA-H award

The U.S. Department of Health and Human Services, by means of the Advanced Research Projects Agency for Health (ARPA-H), at this time introduced as much as $37 million in undertaking funding by means of its Open Broad Agency Announcement (Open BAA) to revive perform to the thymus, an organ chargeable for supporting regular immune cell improvement, and probably restore immune system perform as folks age. More than 10,000 new sufferers are identified annually with a thymus dysfunction, typically associated to congenital defects or most cancers remedies. More broadly, thymus perform naturally declines with age, which might contribute to poorer immune system perform, and result in elevated vulnerability to sickness and poorer well being outcomes.

Wednesday, September 27:

ARPA-H announces award to address the rapidly growing threat of antimicrobial resistance and drive antibiotic discovery to improve health outcomes

The U.S. Department of Health and Human Services (HHS), by means of the Advanced Research Projects Agency for Health (ARPA-H) at this time introduced a brand new undertaking to fight the rising menace of antibiotic-resistant micro organism. Bacterial infections stay a number one explanation for loss of life worldwide and greater than 2.8 million antimicrobial-resistant infections happen annually within the United States, inflicting greater than 35,000 deaths. These infections additionally additional lengthen hospital stays and enhance healthcare prices.

To fight this disaster, ARPA-H is funding by means of its Open Broad Agency Announcement (Open BAA) the Defeating Antibiotic Resistance by means of Transformative Solutions (DARTS) undertaking. DARTS focuses on creating a set of diagnostic and experimental platforms that that may reveal insights into how antibiotic resistance begins, seek for new antibiotics, and quickly determine the appropriate antibiotic to prescribe for a selected an infection in actual time.

DARTS will assist within the stewardship of present antibiotics serving to to make sure that sufferers get the antibiotics they want and never ones that they don’t want. This is a vital part of the technique to protect the effectiveness of antibiotics over time and sluggish resistance to those medicine. The DARTS undertaking additional goals to function a speedy platform for the invention of latest antibiotics from pure samples. Harvard Medical School in Cambridge, Massachusetts leads the multi-institution analysis staff below an settlement of as much as $104 million.

Tuesday, September 26:

To advance President Biden’s Unity Agenda, Biden-Harris Administration announces nearly $115 million in new funding for cutting edge research projects in support of Cancer Moonshot objectives

Today, the Biden-Harris Administration is saying the launch of three main initiatives funded below agreements with the Advanced Research Projects Agency for Health’s (ARPA-H) for radical new methods to detect and deal with most cancers. These analysis initiatives characterize the Agency’s dedication to supporting Cancer Moonshot objectives of lowering most cancers deaths and bettering the standard of life for sufferers. Accelerating the combat in opposition to most cancers is a core part of the President’s Unity Agenda, a set of priorities that Americans from each stroll of life can assist. Today’s announcement helps advance the Agenda, together with the work of the Cancer Moonshot, particularly by serving to to develop novel applied sciences for early detection and remedy of cancers.

ARPA-H announces site selections by launching nationwide health innovation network

Today, the Advanced Research Projects Agency for Health (ARPA-H), an company throughout the U.S. Department of Health and Human Services (HHS), introduced the launch of ARPANET-H, a nationwide well being innovation community anchored by three ARPA-H regional hubs in Dallas, Texas; Boston, Massachusetts; and Washington, D.C. The hubs can be mission-focused, regional facilities with a rising community of spokes from across the nation representing the variety of individuals, settings, and capabilities that embody the American well being ecosystem.