Summary: Researchers are trialing a novel brain-computer interface (BCI) with the potential to rework neurosurgical procedures and affected person care. The Layer 7 Cortical Interface, boasting 1,024 electrodes for unparalleled mind exercise mapping, guarantees new insights into neurological and psychiatric situations. This versatile, ultra-thin gadget is designed for minimal tissue harm, marking a big development in BCI expertise. The examine goals to leverage this detailed information to discover mind capabilities and illness impacts, with hopes of uncovering new therapies.

Key Facts:

1. Innovative Design: The Layer 7 Cortical Interface options 1,024 electrodes on a versatile movie, providing high-resolution mapping of mind exercise.
2. Interdisciplinary Research: A multidisciplinary workforce at Mount Sinai is analyzing the information from this interface to know mind habits relationships and illness results.
3. Clinical Potential: This BCI might considerably enhance the understanding of neurological situations and result in novel therapeutic approaches.

Source: Mount Sinai Hospital

A multidisciplinary workforce of neurosurgeons and neuroscientists from the Icahn School of Medicine at Mount Sinai are the primary in New York to review a brand new brain-computer interface that’s engineered to map a big space of the mind’s floor, in actual time, at resolutions lots of of occasions extra detailed than typical arrays utilized in neurosurgical procedures.

A brain-computer interface (BCI) is a system that deciphers mind indicators and interprets them into instructions for exterior applied sciences. The final purpose of a BCI is to revive perform to sufferers with debilitating neurological situations by enabling them to function digital gadgets utilizing solely their ideas.

The Layer 7 Cortical Interface, developed by Precision Neuroscience Corporation, accommodates 1,024 tiny electrodes spanning an space of 1.5 sq. centimeter, embedded in a versatile movie that conforms to the mind’s floor. The movie is one-fifth the thickness of a human hair and was designed to be implanted and eliminated by neurosurgeons with out damaging mind tissue.

“Mount Sinai has established an international reputation for our ability to conduct the most advanced biomedical and scientific research, for our commitment to exceptional patient care, and for our entrepreneurial approach to generating new treatments and advancements in care,” mentioned Joshua B. Bederson, MD, Chair of Neurosurgery on the Mount Sinai Health System and Co-Founder of Mount Sinai BioDesign.

“This culture of excellence, innovation, and collaboration attracts some of the brightest and best clinicians and researchers in the world who are capable of rapidly translating research breakthroughs into new products and services that provide meaningful benefit to patients and our society.

“We are proud to be one of the leading sites participating in the trials for the new array and eager to see what we learn from the detailed information we will collect and analyze.”

As a part of an open-label, single-arm feasibility examine, Mount Sinai neurosurgeons are quickly inserting the investigational gadget on the floor of the examine individuals’ brains throughout intracranial procedures the place floor mapping is routinely carried out and correlated to evoked potentials (checks that measure the mind’s response to sensory stimulation) or standardized behavioral duties which are routinely carried out as a part of these procedures.

The gadget information high-resolution electrophysiological indicators and the information collected is in comparison with that obtained utilizing standard-of-care cortical floor arrays.

A workforce of Mount Sinai neuroscientists who’ve deep experience in human electrophysiology will analyze and interpret the large quantity of information collected from the gadget.

A secondary goal of the examine is to evaluate the power of the thin-film electrode to map electrophysiological correlates of awake behavioral duties, together with motor, speech, and cognitive duties.

“Despite the vast complexity of activity across the human brain, standard monitoring tools can only capture a tiny fraction of the data we need—from a small handful of areas, or at very slow temporal resolution.

“This low-resolution data significantly limits our understanding of brain function and brain disorders,” says Ignacio Saez, PhD, Associate Professor of Neuroscience, and Neurosurgery, Director of the Human Neurophysiology Laboratory, and Principal Investigator of the trial at Icahn Mount Sinai.

“The new device is exciting because it provides us with an extremely detailed depiction of electrical activity in the brain, capturing thousands of data points per second from a thousand brain sites in each participant.

“By monitoring neuronal activity at this unprecedented resolution, our interdisciplinary team at Mount Sinai hopes to gain important insights into how brain function supports behavior and is affected by disease states.

“Our ultimate goal is to obtain actionable knowledge that will open the door to new treatments for neurological and psychiatric disorders and improve quality of life for our patients.”

Precision Neuroscience was co-founded by Benjamin Rapoport, MD, PhD, Assistant Professor of Neurosurgery at Icahn Mount Sinai, a practising neurosurgeon who has a PhD in electrical engineering and laptop science.

Dr. Rapoport additionally serves because the Scientific Director of Mount Sinai BioDesign, a medical expertise prototyping middle and incubator housed inside the Mount Sinai Health System.

Dr. Rapoport is an fairness proprietor in Precision Neuroscience and serves as their Chief Scientific Officer and a member of their board of administrators. As a college member within the Department of Neurosurgery, he studies to Dr. Bederson.

Neither Dr. Bederson nor Mount Sinai have a monetary curiosity in Precision Neuroscience. All Precision Neuroscience analysis at Mount Sinai is performed by unbiased investigators with out monetary ties to the corporate.

About this neurotech and BCI analysis information

Author: Elizabeth Dowling
Source: Mount Sinai Hospital
Contact: Elizabeth Dowling – Mount Sinai Hospital
Image: The picture is credited to Neuroscience News