The magnitude of Nadal’s and Federer’s absence can be gauged by the fact that the triumvirate have shared the last 13 Grand Slam titles between them and the onus will solely be on the Serb to add to that number.

Incidentally, the last time someone outside the trio won a Grand Slam was at the U.S. Open when Swiss Stan Wawrinka beat Djokovic in 2016.

But Wawrinka also decided against travelling to New York leaving former champions Andy Murray and Marin Cilic as the only other Grand Slam winners besides Djokovic in the draw.

Djokovic has previously said he could win the most Grand Slam titles and become the longest-reigning world number one by the time he retires.

A victory on Sept. 13 at the Arthur Ashe stadium will give him his 18th Grand Slam crown and leave him one short of Nadal’s tally while Federer leads with 20.

The Swiss also holds the record of 310 weeks at number one but Djokovic is steadily progressing towards eclipsing him and has already topped the world rankings for 282 weeks.

Djokovic has said it will, however, be disrespectful to discount the chances of other players in the draw.

“Anyone can win, even more after six months without the tour,” he said last week. “We don’t really know how we’re going to feel on the court.”

Dominic Thiem has had three attempts at ending the Grand Slam hegemony of the Big Three but lost the previous two French Open finals to Nadal while going down to Djokovic in this year’s Australian Open title clash.